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Stendra (Avanafil)
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Stendra

Stendra is a PDE5 inhibitor approved for erectile dysfunction by the FDA on April 27, 2012[1] and by EMA on June 21, 2013. Stendra acts by inhibiting a specific phosphodiesterase type 5 enzyme found in various body tissues, primarily in the corpus cavernosum penis.

Other names for this medication:
Avanafil, Spedra, Stendra

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Also known as: Avanafil

Description

Stendra is FDA-approved anti-impotence drug manufactured by Sunrise Remedies. The active ingredient of Stendra is Stendrafil, which is classified as PDE5 inhibitor and is aimed to treat male sexual dysfunction. Other well-known agents share a similar mechanism of action as Stendrafil: Tadalafil (Cialis), Sildenafil (Viagra) and Vardenafil (Levitra). Once a drug is absorbed into the bloodstream, Stendrafil expands muscles in the walls of blood vessels, thereby increases blood flow into the penis and provides a strong erection. The effect of medication starts in 15-30 minutes after taking and can last up to 6 hours, allowing you to choose the most appropriate time for you and your partner. Stendrafil helps to achieve an erection when sexual stimulation occurs. Stendra doesn't protect you and your partner from sexually transmitted diseases (including HIV) and from pregnancy. Stendra is not intended for the treatment in women and children.

Dosage

Take one pill orally with a full glass of water 15-30 minutes before sexual activity. It may be taken with or without food. Start with 50 mg, if you are undergoing stable alpha-blocker therapy or have other health issues. You should not take the medication more than once a day or more than a recommended dose.

Overdose

If an overdose occurs and you are not feeling well, you should seek emergency medical attention or contact your healthcare provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Stendra are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Stendra if you are allergic to Stendra's components. Do not take Stendra if you are also using organic nitrates, nitrate drug for chest pain or heart condition (e.g., nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate), nitrates as amyl nitrate or nitrite ("poppers"). Do not take Stendra if you take other medication to treat erectile dysfunction, pulmonary arterial hypertension, such as riociguat (Adempas). Do not take Stendra in case you are taking erythromycin, medicines called alpha-blockers, ketoconazole, itraconazole (Sporanox or Nizoral), ritonavir (Norvir) or indinavir (Crixivan). Try not to consume alcohol while using Stendra, as it can lower your blood pressure, causing dizziness and rapid heart rate (tachycardia). Do not drive or operate machinery while taking the medication. Contact you doctor or health care professional right away if the erection lasts longer than 4 hours or if it becomes painful. Stendra does not protect you and your partner from sexually transmitted diseases and pregnancy. Stendra can be dangerous for children and women.

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We assessed temporal trends in diabetes prevalence and key diabetes risk factors (obesity, physical activity, smoking) over 5 years in a nationally representative sample. The use of a pre-treatment with non-linear anisotropic filtering was also compared to non-filtered images. Most recent data also suggest that tissue regeneration and transdifferentiation are controlled by epigenetic functions. sympodialis-exposed MDDCs generated from patients with a high degree of eczema, as measured by SCORAD, compared to healthy controls and patients with a low SCORAD. Using the same method, four of the genes (GHR, PRLR, ALDOB, and MUSK) were assigned to the Japanese quail Z chromosome. Pacific salmon migrate from ocean through the natal river for spawning.

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Risk Factors of Reperfusion Failure following Primary Angioplasty for ST-Segment Elevation Myocardial Infarction (STEMI). LSPRs, however, are not limited to nanostructures of metals and can also be achieved in semiconductor nanocrystals with appreciable free carrier concentrations. On the other hand, the antagonistic action of KCl on opioid analgesia was found to be dependent on the opioid utilized to protect the opioid receptor against the effect of beta-FNA. The clinical outcome of localized PGL treated by chemotherapy alone is similar to that treated by surgery followed by chemotherapy in terms of tumor response, disease-free survival and overall survival, suggesting that surgery be reserved for those with residual tumors after chemotherapy. MGP mRNA was assayed by relative quantitative and real-time PCR. Chart auditing tools for detecting threats to safety are often used. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis. Special attention is dedicated to the case where the probability of mutation is very small and approximations for (i)-(iii) are derived. Since the course remains for a long period at the local and regional levels the treatment of choice is abdomino-perineal amputation.

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The pathway to flavone-C-glucosides comprised a flavanone 2-hydroxylase (F2H), co-expressed with a C-glucosyltransferase (CGT). In any epithelial monolayer, the tight junctions enable the epithelium to form a barrier by joining neighboring cells together and regulating transepithelial diffusion through the paracellular spaces. In this study, a stochastic nonlinear dynamic model is developed for genetic regulatory networks under intrinsic fluctuation and extrinsic noise. During the Legume-Rhizobium symbiosis, hydrogen peroxide (H(2)O(2)) and nitric oxide (NO) appear to play an important signaling role in the establishment and the functioning of this interaction. We do not consider further if the invading strain either still retains the full ecological plasticity of the original populations in Africa, or has already adapted to the invaded area, resulting in a more restricted ability to expand. Recently, it has been recognized that the brain is a frequent site of relapse among ALK-positive patients treated with crizotinib. Three-dimensional LGE MR imaging enables quantitative evaluation of scar tissue mass and transmurality in patients with acute, subacute, or chronic myocardial infarction at significantly reduced acquisition times compared with 2D LGE MR imaging. Using data from a nationally-representative sample of adolescents, we estimate endogeneity-corrected models with school-level fixed effects to identify the effect of alcohol consumption on social network ties.

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Loss of p53 induces changes in the behavior of subventricular zone cells: implication for the genesis of glial tumors. An understanding of the various metabotropic glutamate receptors will be a growing necessity as agents which target them continue to emerge and enter clinical trials. In contrast, run-off assays showed that the yield of the full-length transcripts was markedly enhanced by prior incubation of the DNA fragment with CRP-cAMP. Angiogenesis is suggested to be important for leukemogenesis and chemosensitivity in acute myeloid leukemia (AML). In SV40, however, the Pu box is one of several enhancer elements with different cell specificities.

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