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Parafon (Baclofen)
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Parafon

Parafon is a muscle relaxer. It is used to treat muscular symptoms such as rigidity, tension, and stiffness that may occur due to various conditions such as cerebral palsy, multiple sclerosis, motor neuron disease, or injury to the head, brain, or spine.

Other names for this medication:
Bacfen, Baclof, Baclofen, Bacmax, Chinofen, Liofen, Parafon, Riclofen, Spinofen, Spinospas, Tefsole

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Also known as: Baclofen

Description

Baclofen is used to help relax certain muscles in your body. It relieves the spasms, cramping, and tightness of muscles caused by medical problems, such as multiple sclerosis or certain injuries to the spine. Baclofen does not cure these problems, but it may allow other treatment, such as physical therapy, to be more helpful in improving your condition.

Baclofen acts on the central nervous system (CNS) to produce its muscle relaxant effects. Its actions on the CNS may also cause some of the medicine's side effects. Baclofen may also be used to relieve other conditions as determined by your doctor.

This medicine is available only with your doctor's prescription.

Dosage

This section provides information on the proper use of a number of products that contain baclofen. It may not be specific to Parafon. Please read with care.

Take this medicine exactly as directed by your doctor. Do not take more of it, do not take it more often, or do not take it longer than your doctor ordered.

Measure the oral liquid with a marked measuring spoon, oral syringe, or medicine cup.

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For muscle relaxation: For oral dosage form (solution): Adults and children 12 years of age and older—At first, 5 milliliters (mL) three times a day for 3 days. Your doctor may increase your dose by 5 mL every 3 days as needed and tolerated. However, the dose is usually not more than 80 milligrams (mg) per day (20 mg four times a day). Children younger than 12 years of age—Use and dose must be determined by your doctor. For oral dosage form (tablets): Adults and teenagers—At first, 5 milligrams (mg) three times a day. Your doctor may increase your dose by 5 mg every 3 days until the desired response is reached. However, the dose is not more than 80 mg per day. Children—Use and dose must be determined by your doctor.

Overdose

If you overdose Generic Parafon and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of reach of children.

Side effects

The most common side effects associated with Parafon are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Side effects such as hallucinations, confusion or mental depression, other mood or mental changes, and severe drowsiness may be especially likely to occur in elderly patients, who may be more sensitive than younger adults to the effects of intrathecal baclofen.

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Biochemical investigations in skeletal muscle and expression of the lesion in other cells. Effects of progesterone on learning and memory and P2X7 receptor expression in the hippocampus after global cerebral ischemia/ reperfusion injury in rats. Identification and characterization of human papillomavirus DNA sequences in Italian breast cancer patients by PCR and line probe assay reverse hybridization. To study how implementation of a naturalistic trial design for mirtazapine treatment in major depressive disorder for six (up to 12) months could be used and evaluated by means of clinical efficacy and safety. Utility of multi-detector CT for pre-operative diagnosis of internal hernia through a defect in the broad ligament (2007: 1b). Computed tomography scan of the skull showed that a major part of the squamas of the frontal and temporal bones were transformed into spiculoform structures turned outwards and inwards. Marginal effects were computed to visually depict differences in job insecurity across areas with different levels of unemployment. In this study, a new semi-synthetic berberine analogue, 5,6-didehydro-8,8-diethyl-13-oxodihydroberberine chloride (1), showed nanomolar level potency against in vitro models of leishmaniasis, malaria, and trypanosomiasis as well as activity in an in vivo visceral leishmaniasis model.

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We studied 103 subjects (39 premenopausal women, 18 postmenopausal women and 46 men) during three, randomized, 8-week energy- and nutrient-controlled experimental diets in the Dietary Effects on Lipids and Thrombogenic Activity (DELTA) Study. Differences in the bioclimatic active factors in the area of the German Baltic seacoast and their seasonal variations. Overexpression of PRV-1 gene in polycythemia rubra vera and essential thrombocythemia. The protein is fully functional and enables NMR-based screening and structural studies of this important protein. Therapeutic efficiency of early and late administration of surfactant-BL during bleomycin-induced damage to rat lungs. Plasma phospholipid transfer protein activity is independently determined by obesity and insulin resistance in non-diabetic subjects. Gliding is the simplest form of flight, yet relatively little is known about its mechanics in animals. Determination of the duration of post-vaccinal smallpox immunity by means of hemagglutination-inhibiting antibodies. Antral follicle count, mature oocyte count, age, basal follicle-stimulating hormone (FSH), estradiol (E2), maximum serum E2 levels, and pregnancy success were also compared. The correlation of the wavefront errors with best spectacle-corrected visual acuity, low-contrast visual acuity, and visual acuity under glare conditions was analyzed.

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The primary efficacy outcome measure was the change in central retinal thickness from baseline to Week 26 measured by optical coherence tomography. Reproduction in all mammals is controlled by a hypothalamic clock that produces periodic secretory pulses of GnRH, but how the timing of these pulses is determined is poorly understood. We will review several pediatric phalangeal fracture types that must be recognized and treated appropriately to minimize complications and disability. It is now generally accepted that iron accumulates in the brain during the ageing process. Indiscriminate use of insecticides leads to environmental problems and poses a great threat to beneficial microorganisms. Seasonal incidence of Karoo paralysis in relation to the infestation density of female Ixodes rubicundus. These results underscore the usefulness of investigating explicitly the tempo and mode of climatic niche evolution and its role in determining species distributions. Twelve newly diagnosed and not previously treated women with interstitial cystitis completed a bladder symptom questionnaire the day before undergoing cystoscopy, hydrodistension, and biopsy. Chromosomal ARS and CEN elements bind specifically to the yeast nuclear scaffold. Contextual analysis complements single-cell analysis in the diagnosis of breast cancer in fine needle aspirates.

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The lesions and etiologic agents associated with 13 outbreaks of respiratory disease in commercial chickens were investigated. It was postulated that the iron-sulfur protein (ISP) accepts the first electron from ubiquinol to generate ubisemiquinone anion to reduce b(L). Delivered by DNA immunogens, E2 evokes specific immune response of Th1-type, failing to induce either considerable antibody production, or T-helper cell proliferation. Influence of the environmental context on diabetes self-management: a rationale for developing a new research paradigm in diabetes education. A set of studies recently published by our laboratory illustrating high-throughput identification of allergen specific T-cell epitopes. The glycogen and lipid concentrations in neutrophils in cancer patients were significantly lower than in healthy controls. Findings are compatible with the recent work suggesting research should concentrate on the moderated associations between gender, internalising and externalising symptoms and cortisol, rather than any simple relationship. Consistent with this, E2-independent in vitro HPV replication is inhibited by CDP to a greater extent than E2-dependent replication. Furthermore, in a variety of pathological cases studied, the expression of specific characteristics in culture varied in a fashion similar to differences observed in vivo. An explorative design with a phenomenographic approach was used.

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Anatomical disorders of lower pole collecting system may be considered as factors contributing to stone formation. Design and implementation of a multifrequency near-infrared diffuse optical tomography system. Rabbit corneal epithelial and stromal cells, grown as primary cultures and low-passage isolates, were used as the sources of RNA for RT-PCR with primers specific for mRNAs encoding the proteins that comprise an NADPH oxidase complex. Two case studies that describe the effect of cognitive-communicative disorders on dysphagia are provided. We have shown that 3DE is accurate and reproducible for the measurement of LV volumes for risk assessment in chronic ischemic heart disease and dilated cardiomyopathy. Red pool chlorophylls of photosystem I of the cyanobacterium Thermosynechococcus elongatus: a single-molecule study. As spermatozoa pass through the epididymis they complete a maturation process that enables these cells to participate in the process of fertilization. Medical records of cardiac surgical patients were retrospectively reviewed for preoperative, intraoperative, and postoperative variables, and also prospective follow-up for all-cause mortality. The unit provides a practical reference for laboratory professionals to use in recognizing and addressing essential quality-assurance issues in human molecular genetic testing.

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Surface-antigen expression profiling of B cell chronic lymphocytic leukemia: from the signature of specific disease subsets to the identification of markers with prognostic relevance. The evolution of morphological adaptations to the Iberian semi-arid environments such as the loss of wings (apterism) or the ability to exploit alternative food resources is thought to have promoted diversification. A membrane-lipid peroxidation study involving malondialdehyde production, using liver and epidermal microsomal fractions with and without porphyrins, psoralens, and UVA radiation, indicated 10-20 times increased production of malondialdehyde with UVA and porphyrins than with psoralens. Evaluation of the dextran-charcoal method of radio-immunoassay for insulin. Mosquito bite prevention should be undertaken by all travelers, and methods of deterring mosquito bites should be understood. Changes in Attention Deficit Hyperactivity Disorder Rating Scale IV total scores and Clinical Global Impressions-Improvement scale were used to evaluate the efficacy of lisdexamfetamine dimesylate. The decrease of the goitre rate for the children of the control school might have been due to the activities of a village health volunteer from a nearby village who was using iodized salt for IDD control according to the ongoing national programme initiated by the Ministry of Public Health.

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Palladium-109 and holmium-166 are radionuclides with nuclear, physical and chemical characteristics appropriate for therapeutic purposes. A decision theoretic and prototype conceptualization of possible selves: implications for the prediction of risk behavior. Why you need to look where you step for precise foot placement: the effects of gaze eccentricity on stepping errors. Unnoticed hypoxia was detected in a significant number of the patients admitted in the wards of the hospital. The carboxyl-terminal octapeptide appears invariant in type I proteins and ends in cysteine, which may have a cross-linking function. A comparative study of the pharmacokinetics of propranolol and its major metabolites in the rat after oral and vaginal administration. Twenty-seven participants meeting DSM-IV criteria for SAD with significant public speaking anxiety. Interaction between fermentation temperature and yeast strain was also tested. MANAGEMENT OF CEREBRAL ARTERIAL INSUFFICIENCY CAUSED BY REVERSAL OF FLOW. The frequency of spontaneous emergence of tylenol and motrin infant dose chart resistance was highest with S.

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A false aneurysm in the proper hepatic artery and extravasation from the gastroduodenal artery stump were recognized, and therefore, the proper hepatic artery and common hepatic artery were embolized at a site distal to the false aneurysm using microcoils. There was no statistically significant difference in clinical or radiological outcome between conservative and surgical management. Irrespective of the timing of the examination, there was a significant increase in serum ACE activity (on average 365 U/l, as against 282 U/l, p less than 0.01), if metastasis had occurred. Applications of real-time immuno-polymerase chain reaction (rt-IPCR) for the rapid diagnoses of viral antigens and pathologic proteins. A small purposive sample was selected, and in-depth, open-ended interviews were conducted, in order to generate and explore rich, experiential accounts which are clearly situated and contextualized. Clinical experience utilizing a novel fluoroscopic technique for wire-guided nasojejunal tube placement in the dog: 26 cases (2006-2010). In a computer-assisted search of relevant literature, 82 studies were identified. The outcome measures were quality of sleep (Pittsburgh questionnaire), anxiety (State Anxiety Inventory), depression (Center for Epidemiologic Studies Depression Scale), pain (visual analogue scale, pressure algometry and McGill) and quality of life (Fibromyalgia Impact Questionnaire) before and after a 12-week therapy. Noninvasive in vivo positron emission tomography (PET) studies of cerebral 5-HT(7) receptors could provide a significant advance in the understanding of the neurobiology and eventual flomax 0.4 mg capsule dysfunctions of the 5-HT(7) receptor. The present study aimed to assess the allergenicity of Brassica juncea (mustard) expressing choline oxidase (codA) gene from Arthrobacter globiformis that provides resistance against abiotic stresses.

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Thymic histocultures confirmed that replication of STR-C is particularly susceptible to this cytokine, compared to its STR-B and STR-E counterparts. Effect of selected insecticides on Lygus hesperus (Heteroptera: Miridae) oviposition behavior in cotton. The aim of the study was to evaluate intrahepatic portosystemic venous shunts (IPSVS) patterns and to determine the role of Color Doppler sonography in the diagnosis and evaluation of related hemodynamic changes in portal perfusion. Here we show that this adhesion is inhibited by lectins, including Griffonia simplicofolia isolectin B4 (GSI), which has been used as a microglial marker for many years. Presenting under pressure: communication and international medical graduates. However, analysis of the internal transcribed spacers (ITS1-5.8S-ITS2) of specimens did not confirm this classification. The schedule for the treatment will be determined according to the malformation type and its local or general effects on the brain.

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