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Losaprex

Losaprex belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Losaprex is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

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Also known as: Losartan

Description

Losaprex (losartan) belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.

Losaprex is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Losaprex is also used to slow long-term kidney damage in people with type 2 diabetes who also have high blood pressure.

Dosage

Usual Adult Dose for Diabetic Nephropathy:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Adult Dose for Hypertension:

Initial dose: 50 mg orally once a day Maximum dose: 100 mg orally once a day Comments: -If hypertensive patients with left ventricular hypertrophy or type 2 diabetic nephropathy patients require titration from initial dose, increase to 100 mg orally once a day. -Antihypertension is substantially present within 1 week but in some studies the maximal effect occurred in 3 to 6 weeks. Uses: -Treatment of hypertension. -To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy. -Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (urinary albumin to creatinine ratio 300 mg/g or greater) in patients with type 2 diabetes and a history of hypertension.

Usual Pediatric Dose for Hypertension:

6 Years or Older: Initial dose: 0.7 mg/kg orally once a day (up to 50 mg total) Comments: -May be given as a tablet or suspension. -Doses above 1.4 mg/kg (or 100 mg) daily have not been studied in pediatric patients.

Detailed Losaprex dosage information

Overdose

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Losaprex are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Losaprex if you are allergic to losartan.

Do not use Losaprex if you are pregnant, and tell your doctor right away if you become pregnant. Losartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

To make sure Losaprex is safe for you, tell your doctor if you have:

kidney disease; liver disease; congestive heart failure; an electrolyte imbalance (such as high levels of potassium in your blood); if you are on a low-salt diet; or if you are dehydrated.

You should not breast-feed while using Losaprex.

Losaprex is not approved for use by anyone younger than 6 years old.

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The results demonstrated that the TATA element-dependent basal activity of the pAS8 promoter was stimulated 4-fold by supplementation of a Sp1-depleted HeLa cell nuclear extract (NEd) with purified human Sp1, indicating that pAS8 promoter activity is dependent upon Sp1. MAPKAPK-2-mediated LIM-kinase activation is critical for VEGF-induced actin remodeling and cell migration. As postoperative complications we found an early soft tissue stenosis of the external auditory canal and one late soft tissue stenosis which recurred after revision surgery. The analysis of history allowed to understand the events that occurred in a critical and reflective. Hierarchical accumulation of RyR post-translational modifications drives disease progression in dystrophic cardiomyopathy. Pathology of the sympathetic nervous system corresponding to the decreased cardiac uptake in 123I-metaiodobenzylguanidine (MIBG) scintigraphy in a patient with Parkinson disease. Eight differentially expressed cDNAs were selected, isolated, and characterized. Imbalance of the Epstein-Barr virus-host relationship in AIDS-related complex patients. Re-framing the biaxin suspension storage question: what do we really want to know about rural healthcare ethics?. Impairment of olfaction and mucociliary clearance after expanded endonasal approach using vascularized septal flap reconstruction for skull base tumors.

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Treatment failure in emergency department patients with cellulitis. Wound or suture insufficiency complicating penetrating keratoplasty. In general, sentinel lymph node is the gateway to regional nodal metastasis and beyond. The significance of voltage and wave duration of the stimuli in electromicturition, induced by pelvic nerve stimulation in dogs. Aminoguanidine inhibited nitrite levels and iNOS activity in addition to exerting inhibitory effects on the COX pathway. It is generally thought that a large defect should be treated with bone-grafting, but there is a lack of consensus with regard to how large a defect must be in order to necessitate this procedure. Two amplicon sequencing strategies revealed different facets of the prokaryotic community associated with the anaerobic treatment of vinasses from ethanol distilleries. Study 2 was conducted to determine if CVA patients would perform more poorly than community controls on the CCTFR.

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Synergistic effect of silencing the expression of tick protective antigens 4D8 and Rs86 in Rhipicephalus sanguineus by RNA interference. We report comprehensive structure-activity relationship studies on a novel series of c-Jun N-terminal kinase (JNK) inhibitors. In particular, PARAMO can build 800 different models on a 300,000 patient data set in 3h in parallel compared to 9days if running sequentially. The goal of this study is to identify relationships between objectively measured and subjectively scored parameters and reported pain. We have constructed a robust informatics backbone for this project centered on the DICOM standard and eXtensible Neuroimaging Archive Toolkit (XNAT) server. The isoenzymes of glutamic-oxalacetic transaminase in muscles with predominantly tonic or phasic activity in the fetus and suckling. This study also indicates that the insulinotropic activity of amino acids is restricted to L-amino acids and establishes which amino acids are the strongest stimulators of the insulinotropin sensor in barfin flounder. Unlike other motion encoding techniques, zHARP encodes both in-plane and through-plane motion in a single image plane without affecting the acquisition speed. The intracellular virions contained, predominantly, an immature form of gH and no gH was found on the surface of infected cells. Individual neuroblasts have unique gene expression profiles and give rise to distinct clones of neurons and glia.

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Inflammation and the nervous system: the connection in the cornea in patients with infectious keratitis. It was difficult to diagnose this disease in the early time course of the disease. Novel protein transduction method by using 11R: an effective new drug delivery system for the treatment of cerebrovascular diseases. Sequence analysis of AMACR cDNA from the patients identified two different mutations that are likely to cause disease, based on analysis in Escherichia coli. Dermatofibroma is a common benign fibrohistiocytic lesion that usually appears as a slow-growing, firm dermal nodule with a predilection for the legs of middle-aged women. The data was collected from October to November 2007 and entered using Epi Data Entry and analyzed by SPSS 13.0. These results implied that BnPDK1 was involved in the regulation of fatty acid biosynthesis in developing seeds. Comparison of 2 regimens of chemotherapy of small cell carcinoma of the lung: modified Hansen method and the ACOM method. Diabetes mellitus has become a monumental problem and a major health concern throughout the world.

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