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Clipto (Enalapril)
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Clipto

Clipto is an ACE inhibitor that is used to treat high blood pressure (hypertension). Lowering blood pressure may lower your risk of a stroke or heart attack. Clipto is also used to treat congestive heart failure.

Other names for this medication:
Amprace, Analept, Auspril, Baripril, Bidinatec, Biocronil, Convertase, Cosil, Dinid, Docenala, Ednyt, Enaladil, Enalbal, Enazil, Envas, Eritril, Eupressin, Fibrosan, Glenamate, Hasitec, Hipoartel, Hipopril, Iecatec, Innozide, Jutaxan, Korandil, Lapril, Laprilen, Lenimec, Mepril, Narapril, Nuril, Olinapril, Presopril, Priltenk, Reminal, Renaton, Renistad, Renitec, Revinbace, Silverit, Tenace, Tencas, Tensapril, Tesoren, Ulticadex, Xanef

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Also known as: Enalapril

Description

Enalaprilat injection is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled .

Enalaprilat works by blocking an enzyme in the body that is necessary to produce a substance that causes blood vessels to tighten. As a result, the blood vessels relax. This lowers blood pressure and increases the supply of blood and oxygen to the heart .

This medicine is available only with your doctor's prescription .

Dosage

Usual Adult Dose for Hypertension:

Initial dose: 5 mg orally once a day Maintenance dose: 10 to 40 mg orally per day as a single dose or in 2 divided doses Maximum dose: 40 mg orally daily as a single dose or in 2 divided doses In combination with diuretics: Initial dose: 2.5 mg orally once a day If feasible, the diuretic should be discontinued 2 to 3 days prior to initiation of therapy with enalapril. If required, diuretic therapy may be gradually resumed.

Usual Adult Dose for Congestive Heart Failure:

Initial dose: 2.5 mg orally once a day Maintenance dose: 2.5 to 20 mg daily in 2 divided doses Maximum dose: 40 mg orally per day in 2 divided doses Comments: -Treatment is usually combined with diuretics and digitalis. -Doses should be titrated upward, as tolerated, over a period of a few days or weeks.

Usual Adult Dose for Left Ventricular Dysfunction:

Initial dose: 2.5 mg orally twice a day Maintenance dose: 20 mg orally per day in 2 divided doses Comments: -After the initial dose, the patient should be observed for at least 2 hours and until blood pressure has stabilized for at least an additional hour. -If possible, the dose of any concomitant diuretic should be reduced which may diminish the likelihood of hypotension.

Usual Pediatric Dose for Hypertension:

Children 1 month to 17 years: Initial dose: 0.08 mg/kg/day (up to 5 mg) in 1 to 2 divided doses. Adjust dosage based on patient response. Maximum dose: Doses greater than 0.58 mg/kg (40 mg) have not been evaluated in pediatric patients. Comment: -Not recommended in neonates and in pediatric patients with glomerular filtration rate less than 30 mL/min, as no data are available.

Detailed Clipto dosage information

Overdose

If you overdose Clipto and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Clipto overdosage: fainting, dizziness.

Storage

Store at room temperature below 30 degrees C (86 degrees F) away from moisture and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Clipto are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

You should not use Clipto if you are allergic to enalapril:

you have hereditary angioedema; you recently took a heart medicine called sacubitril; or you have ever had a severe allergic reaction to any ACE inhibitor (benazepril, captopril, fosinopril, lisinopril, moexipril, perindopril, quinapril, ramipril, or trandolapril).

Do not take Clipto within 36 hours before or after taking medicine that contains sacubitril (such as Entresto).

If you have diabetes, do not use enalapril together with any medication that contains aliskiren (a blood pressure medicine).

You may also need to avoid taking enalapril with aliskiren if you have kidney disease.

To make sure this medicine is safe for you, tell your doctor if you have:

kidney disease (or if you are on dialysis); liver disease; or an electrolyte imbalance (such as high levels of potassium in your blood).

Do not use if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Enalapril can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.

You should not breast-feed while you are using Clipto.

Enalapril is not approved for use by anyone younger than 1 month old.

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Students at the Metropolitan Schools and the Degrees of the London University. Previous studies have suggested that the pathogenesis of asthma may be affected by epigenetic regulation. We present a case of malignant transformation of craniopharyngioma with a brief review of relevant literature. The pineal capsule consists of irregular cells with very flat and perforated processes. Of nine injuries treated in the six-year period, six of the patients with ocular injuries from golfing required enucleation. Activity of restriction endonuclease EcoRI was visualised by measurement of the loss of bound DNA after incubation. Nutritional status was evaluated by using modified subjective global assessment (SGA). While most military personnel cope well across the deployment cycle, the operational tempo may raise the risk of mental health problems, such as post-traumatic stress disorder (PTSD) and major depression, and consequences from traumatic brain injury (TBI). In several transformations we have observed an inhibition of repair by neighbouring mismatches. The electrospray ionization ion trap multiple-stage tandem mass spectrometry (ESI-MS(n)) and electrospray ionization Fourier transform ion cyclotron resonance multiple-stage tandem mass spectrometry (ESI-FT-ICR-MS(n)) have been applied successfully to the direct investigation of a number of dibenzocyclooctadiene lignan constituents from the methanol extracts of the Fructus Schisandrae in the positive ion mode.

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Methionine residues around phosphorylation sites are preferentially oxidized in vivo under stress conditions. The breakpoint on chromosome 13q31 was in a 1-megabase (Mb)-gene desert. The highest concentration of isovitexin occurred between pre-flowering and flowering stages. Metal selectivity of exocytosis in alpha-toxin-permeabilized bovine chromaffin cells. In this multi-functional process of underwater attachment, curing of the adhesive is crucial for the formation of a secure attachment. The incidence of malpositions are varied according to various studies and depend on the experience of the operator performing the cannulation. Push-pull strategy in the regulation of postembryonic root development.

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The dose-dependence of AUC was investigated in 12 healthy volunteers (25, 50, 100, and 400 mg rac-talinolol as single p.o. Learning global health: a pilot study of an online collaborative intercultural peer group activity involving medical students in Australia and Indonesia. Low vision rehabilitation for a target-shooting marksman with visual field loss and diplopia. Damage to the hexon protein, however, appeared to affect only regions not directly involved in the infectious cycle. Regression analyses using baseline and postintervention (6 weeks) data from an ongoing randomized controlled trial. Conditions that may involve altered endocrine function were also more frequent among such persons. tenormin generic The genetics of proximal femur geometry, distribution of bone mass and bone mineral density. Tensile strength was obtained with a cyclic loading tensile testing machine and tendon width and height measurements were obtained through digital analysis by photographs of the repairs.

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Uranium interaction with two multi-resistant environmental bacteria: Cupriavidus metallidurans CH34 and Rhodopseudomonas palustris. To evaluate the accuracy of magnetic resonance (MR) cholangiopancreatography in the diagnosis of anatomic variants of the biliary tree. Electromechanical delay in human skeletal muscle under concentric and eccentric contractions. Researchers evaluated whether a new device might decrease the time required for catheter insertion, increase the likelihood of inserting the catheter on the first attempt (improved accuracy), and reduce patient discomfort. The progress of serotonin-induced renal lesions was studied over a period of 6 mth following a single intraperioneal injection of 40 mg/kg serotonin. The efficacy of longitudinal durotomy with regard to prevention of postoperative palsy was investigated in a controlled study. Phase II study of central nervous system (CNS)-directed chemotherapy including high-dose chemotherapy with autologous stem cell what is the purpose of flagyl tablets transplantation for CNS relapse of aggressive lymphomas.

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To assess the wall apposition of 3 distal protection filters used in carotid artery stenting (CAS) for cerebral protection and quantify the effect on the in vitro capture efficiency of the filters under simulated physiological flow conditions. Compared to the group of administrative workers receiving doses below 1 mSv/year, limit recommended by the ICRP for public exposure, the micronucleus frequency was slightly increased in the group of radiation workers, exposed occupationally. To clarify the involvement of nitric oxide (NO) in the postsynaptic regulation of the rabbit iris sphincter muscle tone, the authors examined the effects of NO-related agents on the cholinergic contraction induced by carbamylcholine (carbachol) and the tachykinergic contraction induced by neurokinin A. ICAM-2 is expressed on a variety of leukocyte cell lines, including T and B lymphoma, mastocytoma, and macrophage lines. Prolonged coinfection with GB virus C (GBV-C) has been associated with improved survival in human immunodeficiency virus (HIV)-infected adults. We surveyed internal medicine residents and nocturnists to determine their satisfaction with transfers in terms of safety, efficiency, and usefulness of information provided at the time of transfer. Therefore, it appears that plants have evolved specialized mechanisms to execute formative cell divisions. Lung-reduction surgery can produce increases in the elastic recoil of the lung in patients with diffuse emphysema, leading to short-term improvement in dyspnea and exercise tolerance. In lean mice fed on diets containing a constant percentage of carbohydrate and protein, increasing the fat content of the diet (and decreasing the proportion of cellulose) produced a decrease in fatty acid synthesis in liver, adipose tissue and rest of carcass, when the measurements were made during the night-time feeding period.

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